Dr. Amir Faisal received his PhD in Cell Biology from Friedrich Miescher Institute for Biomedical Research/University of Basel, Switzerland in 2004. During his PhD he identified novel roles for Shc protein, an important adaptor downstream of tyrosine kinases, in insulin signalling and cytoskeletal reorganization. He received his first postdoctoral training (2004-2008) in Protein Phosphorylation Laboratory at London Research Institute where he discovered that another adaptor protein, MyD88, couples Protein Kinase C epsilon to Toll like receptors during innate immunity. From 2008 to 2014, he worked at Cancer Therapeutics Unit of Institute of Cancer Research in Sutton first as postdoctoral fellow and later as senior scientist. He played an important role in progression of several drug discovery projects, one of which resulted in discovery of a pre-clinical development candidate that will undergo phase I clinical trials in 2016. After joining LUMS in August 2014, he has been establishing a cancer therapeutics lab at SBASSE.\

URL: http://biolabs.lums.edu.pk/cancer

Title Publication Author Year
Targeting carbonic anhydrases II/IX/XII with novel series of coumarin-based compounds: Synthesis, biological activity and molecular dynamics analysis Journal of Molecular Structure 2024
Synthesis and characterization of bis-amide SSE1917 as a microtubule-stabilizing anticancer agent Bioorganic Chemistry 2024
Repurposing of investigational cancer drugs: Early phase discovery of dengue virus NS2B/NS3 protease inhibitors Archiv der Pharmazie 2023
Design, Synthesis, and Biological Evaluation of SSE1806, a Microtubule Destabilizer That Overcomes Multidrug Resistance ACS Medicinal Chemistry Letters 2023
Chemical Synthesis of Selenium-containing Peptides Mini-Reviews in Medicinal Chemistry 2023
Spontaneous NETosis in diabetes: A role of hyperglycemia mediated ROS and autophagy Frontiers in Medicine 2023
Selenium-containing Peptides and their Biological Applications Current Medicinal Chemistry 2022
Synthesis and Characterization of Griseofulvin Derivatives as Microtubule-Stabilizing Agents ChemistrySelect 2022
Combined 3D-QSAR, molecular docking and dynamics simulations studies to model and design TTK inhibitors Frontiers in Chemistry 2022
Identification and Characterization of Natural and Semisynthetic Quinones as Aurora Kinase Inhibitors Journal of Natural Products 2022
Synthesis and Evaluation of Novel Carboxamides Capable of Causing Centrosome Declustering and Apoptosis in Breast Cancer Cells ChemistrySelect 2022
Reduction-Sensitive Dextran-Paclitaxel Polymer-Drug Conjugate: Synthesis, Self-Assembly into Nanoparticles, and in Vitro Anticancer Efficacy Bioconjugate Chemistry 2021
Polycomb Requires Chaperonin Containing TCP-1 Subunit 7 for Maintaining Gene Silencing in Drosophila Frontiers in Cell and Developmental Biology 2021
CCT245718, a dual FLT3/Aurora A inhibitor overcomes D835Y-mediated resistance to FLT3 inhibitors in acute myeloid leukaemia cells British Journal of Cancer 2021
A Personalized Therapeutics Approach Using an In Silico Drosophila Patient Model Reveals Optimal Chemo- and Targeted Therapy Combinations for Colorectal Cancer Frontiers in Oncology 2021
Synthesis of diosgenin conjugated gold nanoparticles using algal extract of Dictyosphaerium sp. and in-vitro application of their antiproliferative activities Materials Today Communications 2021
Glyceryl Monostearate Based Solid Lipid Nanoparticles for Controlled Delivery of Docetaxel Current Drug Delivery 2021
Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors Journal of Natural Products 2020
Colon specific enzyme responsive oligoester crosslinked dextran nanoparticles for controlled release of 5-fluorouracil International Journal of Pharmaceutics 2020
Transcriptomic analysis reveals differential gene expression, alternative splicing, and novel exons during mouse trophoblast stem cell differentiation Stem Cell Research and Therapy 2020
A cell-based high-throughput screen identifies inhibitors that overcome P-glycoprotein (Pgp)mediated multidrug resistance PLoS ONE 2020
Quizartinib-resistant FLT3-ITD acute myeloid leukemia cells are sensitive to the FLT3-Aurora kinase inhibitor CCT241736 Blood Advances 2020
A facile and versatile route to functional poly(propylene) surfaces via UV-curable coatings Reactive and Functional Polymers 2019
Metabolism of the dual FLT-3/Aurora kinase inhibitor CCT241736 in preclinical and human in vitro models: Implication for the choice of toxicology species European Journal of Pharmaceutical Sciences 2019
Effect of Extraction Methodologies on Antioxidant Potential and Synergistic Anticancer Behavior of Leaf Extract of Polygonum amplexicaule Against HCT-116 Cells Iranian Journal of Science and Technology, Transaction A: Science 2019