Research group page:
Google Scholar:

Dr. Rahman Shah Zaib Saleem joined LUMS in 2012 as an assistant professor and was tenured and promoted to associate professor in 2020.  He is an enthusiastic experienced organic chemist with a proven track record in medicinal chemistry and materials. He enjoys teaching and training organic chemistry, spectroscopy, medicinal chemistry and drug discovery courses to undergraduate and postgraduate students. He builds effective collaborations within and outside of the institution.

In medicinal chemistry, he has expertise in the discovery of lead molecules for various cellular targets. His specialties include hit and lead generation, lead optimization, medicinal chemistry, organic synthesis and methodology, structure-based drug design, data analysis, natural product isolation and structure elucidation.

On the materials front, he is also working on the novel metal-free organic dyes for solar cell and organic scaffolds for metal-organic frameworks (MOFs) and modification of the drug molecules to prepare nanoparticles for subsequent evaluation. As an organic chemist, he has also done the isolation, characterization & total synthesis of natural products.

Post-doctoral/Work experience
Jan 2020- to date     Associate Professor (tenure), Department of Chemistry & Chemical Engineering, SBASSE, LUMS
Jan 2012- Jan 2020     Assistant Professor, Department of Chemistry & Chemical Engineering, SBASSE, LUMS
Summer 2019    DAAD fellow, University of Saarland, Germany
Summer 2016    DAAD fellow, University of Saarland, Germany
Summer 2014    Herchel Smith Post-Doctoral Fellow, University of Cambridge, UK
Summer 2012    Post-Doctoral Research Visit, University of Bristol, UK


2011      PhD, Michigan State University (Advisor: Prof. Jetze J. Tepe, Fulbright Fellowship)
2004      MPhil, GC University, Lahore, Pakistan
2002      MSc, GC University, Lahore, Pakistan (First position in the university)
2000      BSc, Punjab University, Lahore (Government College, Gujranwala), Pakistan

Roll of Honors
Academic roll of honor (2002)


2019                     DAAD Research Stays for University Academics and Scientists, University of Saarland
2016                     DAAD Research Stays for University Academics and Scientists, University of Saarland
2013-14                Herchel Smith fellowship, University of Cambridge
2012                     LUMS’ SSE Deans travel award for the summer research visit to University of Bristol
2006-11                Fulbright PhD fellowship
2011                     Dissertation completion fellowship
2011                     Graduation school travel fellowship, Michigan State University
2006                     Walter R. and Margaret W. Yates Memorial fellowship, Michigan State University
2006                     XIVth star award 2005: 125 distinguished men & women: Leaders of the new millennium
2003                     Orient Dr. Ata-ur-Rehman chemistry award and gold medal
2002                     Academic excellence award, GC University Lahore
2002                     Prof. Abdul Rashid Tariq gold medal
1998                     President talent farming award
1996                     Jamiat gold medal

Title Publication Author Year
Effect of nano-morphologies on catalysis and non-enzymatic glucose sensing Journal of Materials Research Nazish Y., Sabahat S., Saleem R.S.Z., Saira F., Yaqub A., 2024
Synthesis and characterization of bis-amide SSE1917 as a microtubule-stabilizing anticancer agent Bioorganic Chemistry Iqbal S., Firdous F., Furqan M., Bilal A., Fozail S., Pohl S.O.-G., Doleschall N.J., Myant K.B., Singh U., Emwas A.-H., Jaremko M., Faisal A., Saleem R.S.Z., 2024
Fabrication of nickel ferrite@MWCNTs for super-capacitor applications Journal of Applied Electrochemistry Zahra N., Sabahat S., Saira F., Saleem R.S.Z., Rahim A., Khan Z.U.H., Nazir F., 2024
Discovery and prospects of new heterocyclic Isatin-hydrazide derivative with a novel role as estrogen receptor ?? degrader in breast cancer cells Frontiers in Chemistry Arif M.N., Sarwar S., Firdous F., Saleem R.S.Z., Nadeem H., Alamro A.A., Alghamdi A.A., Alshammari A.H., Farooq O., Khan R.A., Faisal A., 2024
Heterocyclic pyrimidine derivatives as promising antibacterial agents European Journal of Medicinal Chemistry Ahmed K., Choudhary M.I., Saleem R.S.Z., 2023
Selenoneine-inspired selenohydantoins with glutathione peroxidase-like activity Bioorganic and Medicinal Chemistry Alhasan R., Martins G.M., de Castro P.P., Saleem R.S.Z., Zaiter A., Fries-Raeth I., Kleinclauss A., Perrin-Sarrado C., Chaimbault P., da Silva Junior E.N., Gaucher C., Jacob C., 2023
Design, Synthesis, and Biological Evaluation of SSE1806, a Microtubule Destabilizer That Overcomes Multidrug Resistance ACS Medicinal Chemistry Letters Firdous F., Riaz S., Furqan M., Fozail S., Fatima K., Pohl S.O., Doleschall N.J., Myant K.B., Kahfi J., Emwas A.-H., Jaremko M., Chotana G.A., Saleem R.S.Z., Faisal A., 2023
Surface plasmon resonance-based synthesis of gold nanorods for sensing applications Chemical Papers Sabahat S., Ejaz M., Saira F., Saleem R.S.Z., Nazish Y., Khalil L., Naeem A., 2023
Imidazolium and benzimidazolium sulfonyl salts: Versatile functional group transfer reagents Tetrahedron Letters Nawaz I., Bashir M., Saleem R.S.Z., Chotana G.A., 2023
Investigation of Temperature- and Frequency- Dependent Dielectric Study of LiNi<inf>0.3</inf>Co<inf>0.3</inf>Mn<inf>0.3</inf>O<inf>2</inf> and LiNi<inf>0.3</inf>Co<inf>0.3</inf>Mn<inf>0.3</inf>Ba<inf>0.1</inf>O<inf>2</inf> for Cathode Materials Journal of Physical Chemistry C Ullah L., Imran Z., Sabahat S., Shah S.A.A., Saleem R.S.Z., 2023
Synthesis and Photophysical, Electrochemical, and DFT Studies of Piperidyl and Pyrrolidinyl Chalcones ACS Omega Baig H., Iqbal A., Rasool A., Hussain S.Z., Iqbal J., Alazmi M., Alshammari N., Alazmi A., AlGhadhban A., Sulieman A.M.E., Said K.B., Rehman H.-U., Saleem R.S.Z., 2023
Synthesis, photophysical, voltammetric, and DFT studies of 4-aminochalones Journal of Photochemistry and Photobiology A: Chemistry Baig H., Irfan R., Rasool A., Hussain S.Z., Siddique S.A., Iqbal J., Alazmi M., Alshammari N., Alazmi A., AlGhadhban A., Sulieman A.M.E., Said K.B., Rehman H.-U., Saleem R.S.Z., 2023
Potent heteroaromatic hydrazone based 1,2,4-triazine motifs: synthesis, anti-oxidant activity, cholinesterase inhibition, quantum chemical and molecular docking studies Journal of Molecular Structure Ahmed K., Bashir M., Bano R., Sarfraz M., Khan H.U., Khan S., Sharif A., Waseem A., Gilani M.A., Batool K., Idrees R., Rauf A., Saleem R.S.Z., Arshad M., 2023
Perplexing Polyphenolics: The Isolations, Syntheses, Reappraisals, and Bioactivities of Flavonoids, Isoflavonoids, and Neoflavonoids from 2016 to 2022 Life Umer S.M., Shamim S., Khan K.M., Saleem R.S.Z., 2023
Centrosome Clustering &amp; Chemotherapy Mini-Reviews in Medicinal Chemistry Firdous F., Raza H.G., Chotana G.A., Choudhary M.I., Fai-Sal A., Saleem R.S.Z., 2023
Chemical Synthesis of Selenium-containing Peptides Mini-Reviews in Medicinal Chemistry Ahmed K., Chotana G.A., Faisal A., Saleem R.S.Z., 2023
Selenium-containing Peptides and their Biological Applications Current Medicinal Chemistry Ahmed K., Ashraf D., Chotana G.A., Faisal A., Khan K.M., Saleem R.S.Z., 2022
Synthesis and Characterization of Griseofulvin Derivatives as Microtubule-Stabilizing Agents ChemistrySelect Firdous F., Ibrahim R., Furqan M., Khan H., Raza H., Singh U., Emwas A.-H., Jaremko M., Chotana G.A., Faisal A., Saleem R.S.Z., 2022
Indole-Containing Natural Products 2019???2022: Isolations, Reappraisals, Syntheses, and Biological Activities Molecules Umer S.M., Solangi M., Khan K.M., Saleem R.S.Z., 2022
Synthesis, photophysical, electrochemical and computational studies of novel 2-aminoimidazolones with D-??-A framework Journal of Photochemistry and Photobiology A: Chemistry Baig H., Rasool A., Hussain S.Z., Iqbal J., Ashraf R.S., Emwas A.-H., Alazmi M., Gao X., Chotana G.A., Habib-ur-Rehman, Saleem R.S.Z., 2022
Identification and Characterization of Natural and Semisynthetic Quinones as Aurora Kinase Inhibitors Journal of Natural Products Furqan M., Fayyaz A., Firdous F., Raza H., Bilal A., Saleem R.S.Z., Shahzad-Ul-Hussan S., Wang D., Youssef F.S., Al Musayeib N.M., Ashour M.L., Hussain H., Faisal A., 2022
Synthesis Of Some N-(Un/Substituted-Phenyl)-2-(4-Phenyl-1-Piperazinyl)Acetamides as Possible Antibacterial and Anticancer Agents with Mild Cytotoxicity Pharmaceutical Chemistry Journal Abbasi M.A., Nazir M., Aziz-ur-Rehman, Siddiqui S.Z., Shah S.A.A., Saleem R.S.Z., Shahid M., Mirza B., Ismail H., 2022
Synthesis and Evaluation of Novel Carboxamides Capable of Causing Centrosome Declustering and Apoptosis in Breast Cancer Cells ChemistrySelect Farrukh U.B., Bilal A., Zahid H., Iqbal M., Manzoor S., Firdous F., Furqan M., Azeem M., Emwas A.-H., Alazmi M., Gao X., Saleem R.S.Z., Faisal A., 2022
Iridium-Catalyzed C-H Borylation of CF<inf>3</inf>-Substituted Pyridines ACS Omega Shahzadi H.T., Fatima S., Akhter N., Alazmi M., Nawaf A., Said K.B., Alghadhban A., Sulieman A.M.E., Saleem R.S.Z., Chotana G.A., 2022
Synthesis and evaluation of novel 1, 2, 4-substituted triazoles for urease and anti-proliferative activity Pakistan Journal of Pharmaceutical Sciences Ali S., Siddiqui S.Z., Abbasi M.A., Aziz-Ur-Rehman, Shah S.A.A., Khan K.M., Saleem R.S.Z., Manzoor S., Ashraf M., Zia-Ur-Rehman, 2022